What are the Different Types of Glutathione Available?

8 min read

Essential Takeaways

  • Nano glutathione delivers the effectiveness of IV treatment with the convenience of at-home use
  • Traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness
  • IV Glutathione is the most superior type, but it is inconvenient and will cost hundreds of dollars per session

You know the dangers of oxidative stress; how free radicals can damage cells and lead to an assortment of health problems such as cancer and Alzheimer’s. You may also be aware that Glutathione is a powerful natural antioxidant and one of the most effective weapons against oxidative stress.

When you finally decide to start taking glutathione – and we recommend you begin as soon as possible – you might run into some confusion. You’ll discover there are several different forms of Glutathione from oral to Nano Glutathione and even IV drips.

Even worse, you might find conflicting information about the effectiveness of various forms and formulas of Glutathione, with different companies giving divergent narratives.

So we’ve put together a comprehensive list of the major types of Glutathione and information on the effectiveness of each. Before you start taking any Glutathione supplementation, read this.

IV Glutathione

Intravenous (IV) Glutathione is administered directly into the blood stream through the veins. The IV drip is set up and monitored by a trained medical specialist in a clinical setting. The length of treatment is around 30 minutes to 1 hour with immediate recovery. Usually, a course of 3 to 5 IV Glutathione treatments will be recommended by the doctor.


  • Highly effective at boosting Glutathione levels in the body.
  • Short treatment period with no recovery time necessary.


  • Inconvenient. You have to go to a doctor’s office for the treatment.
  • Expensive. It can cost several hundred dollars per visit.

Nano Sublingual Glutathione

Nano glutathione delivers the effectiveness of IV treatment with the convenience of at-home use. Instead of swallowing a capsule, this moderately priced form of Glutathione involves sublingual drops which are placed under the tongue.

Most of the dosage is delivered directly into the blood stream through the mucous membranes in your mouth. This is why its effectiveness is comparable to that of Glutathione IV drips.


  • Effective at increasing Glutathione levels in the body.
  • Convenient since you can take it at home.


  • Pricier than traditional oral Glutathione (though significantly less expensive than IV Glutathione).

Traditional Oral Glutathione

Oral Glutathione supplements are one of the most popular and oldest ways to increase levels of Glutathione in the body. They come in capsule, tablet or liquid form.

But traditional oral Glutathione supplements are rapidly falling out of favor as new research uncovers their ineffectiveness. Because they have to pass through the digestive tract, very little of the original dosage survives the acidic stomach environment. What’s left is not enough to significantly increase the amount of intercellular glutathione. Thus no benefits are conferred by these supplements.


  • Inexpensive.
  • Can be bought over the counter and taken at home.


  • Ineffective in increasing Glutathione levels.

Oral Liposomal Glutathione

To counter the disadvantages of traditional oral Glutathione supplements, researchers have come up with a new and better form of oral Glutathione. It is called Liposomal Glutathione.

Though usually taken orally, liposomal Glutathione is able to survive the journey through the gastrointestinal system and safely reach target cells. 

How does it do this?

It’s all in how the dosage is transported. To design an effective transportation mechanism, experts borrowed from how substances in the body are transported. The body uses vesicles – a special sac with a fluid in it and surrounded by a fat layer – to transport materials to and from cells. The outer membrane of the vesicle is similar to a cell membrane, making it easy for the two to fuse. The vesicle is able to easily transfer its contents into the cell.

Artificial vesicles, called liposomes, work the same way. Glutathione is carried inside these tiny sacs with a lipid layer on top for protection. They also have a membrane similar to that of a cell. Thus, Liposomal Glutathione can reach target cells while still largely intact unlike traditional oral Glutathione.


  • More effective than traditional oral supplements.
  • Moderately priced.
  • Can be taken at home.


  • Not as effective as IV Glutathione or Nano Glutathione.
  • More expensive than traditional oral Glutathione.
  • Only moderately effective raising they body’s Glutathione levels.
  • Have a very short shelf life due to the Lipid layer

Acetyl Glutathione

Acetylation is a common process in medicine. It involves the addition of an acetyl group into a chemical compound. In fact, both aspirin and heroin contain acetyl. When added to oral glutathione, acetyl makes it more stable. The supplement can therefore pass through the digestive tract without undergoing the same severe degradation that traditional oral glutathione does.

Research is still ongoing on the effectiveness of Acetyl Glutathione but early studies and anecdotal evidence shows a slight increase in Glutathione levels after taking it.

As with Liposomal Glutathione, Acetyl Glutathione was developed to provide a more effective way to orally take Glutathione supplements.


  • Moderately effective.
  • Easy and convenient at-home use.


  • More expensive than most other oral supplements mostly because of the complex production process.
  • Production process requires toxic chemicals that are not natural.

Remember in order to minimize free radical production that a diet rich in fresh fruits and vegetables has been shown to be beneficial. Exercise and rest also can be beneficial. Additionally, you may consider supplementing with glutathione and to ensure optimal levels, we recommend using Nano Glutathione. Click the link below for a special discount plus free bottle offer.   

Glutathione has been shown to provide health benefits and be supportive in relation to a large number of conditions. In order to maintain optimal glutathione levels, consider supplementing with Nano Glutathione.

Click on the Doctor-Curated Combinations below to browse pre-selected combinations designed to work together to produce optimal results.

Doctor-Curated Combinations

Clinically supported, pre-selected and pre-packaged. Designed to work together to produce optimal results.

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